Apply the Nike Memorial Day promo code “START” to take an extra 20% off the sale price of $53 here, bringing the Nike Run Defy Shoes down to $42. You’d pay the full price of $65 for most colors of these shoes today at Amazon. This is a road running shoe with a foam midsole, breathable upper, and rubber outsole for traction. The coupon expires on May 28, 2026. Shop Now at Nike